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doi: 10.1113/jphysiol.2006.122432

Only half of the patients had an optimal pharmacokinetic profile with the low-dose melatonin tested

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Older data, much of which included AED polytherapy, indicated that barbiturates and phenytoin may cause congenital heart malformations, orofacial clefts, and other malformations

Despite these flaws, a subsequent, higher quality study found kava to be more effective than a placebo at improving sleep quality and reducing anxiety ( Interestingly, kavas effects on insomnia may stem from its effects on anxiety

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