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Stem Cells 8 (5), 185201

The activation of NOX and iNOS can cause the production of ROS and RNS, resulting in the depletion of GSH and GPX and aggravating lipid peroxidation [54]

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Moreover, they manifest an array of phenotypic changes, including features of proteotoxic stress, as evidenced by an increased sensitivity to inhibitors targeting protein folding and turnover, elevated replication stress and accumulation of DNA damage and structural rearrangements, activation of the innate immune response and reduced translation 5,8,9,10,11,12,13

To this end, we used the domain level information reported in the study of Wang et al

1,4 SUSTAIN 5: add-on basal insulin 1,10 In adult patients with type 2 diabetes on basal insulin metformin Mean change in A1C from baseline at Week 30 Patients with A1C 8% at screening had their background basal insulin dose reduced by 20% at the start of the trial to limit the potential risk of hypoglycemia