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These assaults cause mutations and losses of genetic material that impair mitochondrial function, thereby blocking melanin synthesis

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first, being downstream of two genes with reduced expression in the mevalonate portion of the pathway, their increased expression could serve to more rapidly allow these cells to achieve pathway functionality at or near wildtype, or higher, levels for zymosterol production and second, ERG6 functions directly downstream of these genes and increasing the substrate when the enzyme is limited may increase conversion to fecosterol overall to facilitate completion of the late pathway to result in ergosterol production at more normal levels