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Moreover, SARS-CoV-2 degrades checkpoint kinase (CHK)1 (190), an effector downstream to Ataxia telangiectasia and Rad3 related protein (ATR) that earlier had been demonstrated to be induced in SARS-CoV-2-infected Vero-6 cells (284)

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In summary, the CPZ model has been shown to mimic many aspects of human demyelinating diseases such as MS, and to be a useful experimental approach to study these diseases and test potential therapies, especially after its standardization on C57BL/6 mice (Vega-Riquer et al., 2019

& Hedlund, B