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Among them, the cereblon-based PROTAC 9 (GDC-11) (D max = 33%) is the most cytotoxic with an IC 50 value of 12 M in HT-1080 cells and is able to induce ferroptosis
Fitoterapia 110 , 5258 (2016)

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In females, high estrogen levels provide neuroprotection by reducing oxidative stress, inflammation, and dopaminergic neuron loss [67, 68, 69, 70]

Ferroptosis suppressing protein 1 (FSP1) protects cells from ferroptosis by acting as a redox enzyme that consumes NADH/NADPH to reduce coenzyme Q 10 (CoQ 10 )
