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Its core physiological effects include increasing mixed venous oxygen content and reversing hypoxic pulmonary vasoconstriction, thus significantly reducing pulmonary arterial pressure and pulmonary vascular resistance (Ficial et al., 2021

GHK-Cu has been shown to improve wound healing, stimulate collagen growth, boost the immune system, and promote the development of blood vessels

[6] [7] In silico modelling suggest that it has effects on thyroid hormone receptors

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The X-box-binding protein-1 (XBP1), spliced and activated by IRE1, is downregulated in glomerular mesangial cells, weakening the inhibitory effect on the phosphatase and tensin homolog (PTEN)/Akt pathway, thereby aggravating kidney damage