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In 2016, this classification was updated in order to include molecular findings such as diagnostic biomarkers and prognostic factors (5)

Coelho et al., 2012
Succinate and fumarate, two TCA intermediates, can inhibit TET and jmjC demethylases

Giannoulia-Karantana A, Vlachou A, Polychronopoulou S et al (2007) Melatonin and immunomodulation: connections and potential clinical applications

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PMC 2957137