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Study limitations Although the current findings are consistent and coherent, strongly indicating the external validity of the study, we do recommend future preferably large prospective clinical trials, to increase their internal validity

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At the molecular level, Western blot analysis revealed that bergamot DFs enhanced the expression of liver proteins involved in cholesterol breakdown, such as LXR and CYP7A1, while reducing the expression of lipogenic proteins including SREBP-1c, FAS, ACC, and SREBP-2

It is important to note that while certain recommendations listed are based on evidence-based findings

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More rigorous, large-scale, RCTs are needed to establish the KD's efficacy and safety in managing autism symptoms
