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Although doxorubicin (DOX) chemotherapy is widely used to treat malignant tumors, its cardiotoxicity restricts its widespread use

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Additionally, Metformin may alter gut bacteria, potentially leading to intestinal bacterial overgrowth that further hinders B12 uptake

Its role as an antioxidant and free radical scavenger is crucial in protecting cells from oxidative stress, contributing to overall cellular longevity