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In contrast, increased frontal activation and/or normalization of abnormal connectivity have been associated with improvement of pain and of sad mood (Li et al., 2018

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This decrease is correlated to lean body mass

2432 Proposed mechanisms by which ALA may exert an anti-nociceptive effect focus on its anti-inflammatory properties, both through reduction of oxidative stress and modulation of cell signaling pathways that may affect gene expression

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