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Specifically, melatonin suppresses proinflammatory cytokines (e.g., IL-1, IL-6, tumor necrosis factor- (TNF-), and interferon- (IFN-)) and enhances anti-inflammatory cytokines (e.g., IL-4 and IL-10) by inhibiting the NF-B pathway, although its low-dose transient proinflammatory effects highlight dose- and pathology-dependent dynamics

[DOI] [PubMed] [Google Scholar] 37.Kremer M.L

This not only enhances their inflammatory potential but also affects antigen processing, glutathionylation of signaling proteins, and interactions with resident CNS cells such as microglia and astrocytes (Federici et al., 2024)

Lipids primarily consist of glycerol and fatty acids

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this depends on their concentration and the nature of the surrounding molecules (Puglia and Powell 1984