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Additionally, oxidative stress, lipid peroxidation, and iron homeostasis imbalance exacerbate the aggregation of Htt with other proteins, leading to increased glutamate excitotoxicity, disrupted mitochondrial function, altered autophagy mechanisms, impaired axonal transport, and ultimately neuronal degeneration, thereby causing the motor, cognitive, and behavioral symptoms of HD (Reichert et al., 2020)

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Melatonin synthesis in the epiphysis was assessed by quantifying the excretion of 6-sulfatoxymelatonin in urine

B12 injections have been shown to support brain health by enhancing cognitive function, improving memory, and reducing the risk of neurodegenerative conditions like dementia and Alzheimers disease

Dietary nitrate restores compensatory vasodilation and exercise capacity in response to a compromise in oxygen delivery in the noncompensator phenotype

Long-term clinical outcomes after early initiation of RRT in critically ill patients with AKI