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This structural relationship has made Dihexa useful for comparative investigations of angiotensin-derived compounds, structure-activity relationships, peptide-derived signaling modulators, and the molecular determinants governing receptor-associated signaling pathways.

Gene set enrichment analysis (GSEA) was performed using the fgsea R package on the ontology gene sets retrieved from gsea-msigdb.org ( An FDR threshold of 0.1 was implemented

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