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Pain Processing Mechanisms Central Sensitization (via mGlu2 receptor upregulation)[4][5] Neuroinflammation (modulates glial activation)[12][13] Mitochondrial Dysfunction (enhances ATP production, -oxidation)[2][13] Oxidative Stress (direct antioxidant activity)[2][13] Systemic Inflammation limited direct evidence SUMMARY OVERVIEW CLINICAL PEARLS 1

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[DOI] [PMC free article] [PubMed] [Google Scholar] 123.Zhang P, Judy M, Lee SJ, Kenyon C

46 In a similar vein, the permeability of dissolved gases, including oxygen 47,48 and carbon dioxide, 49 is decreased by the presence of cholesterol