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This binding allows the complex to translocate into the nucleus, where it binds to an androgen response element (ARE), which further regulates gene expression (Heemers & Tindall, 2007)

doi: 10.1016/j.brainres.2009.06.060

ROS play a crucial role in the pathogenesis of AD because, by reacting with all macromolecules (lipids, proteins, nucleic acids, and carbohydrates), they promote a chain reaction that leads to damage and cell death

The samples for hepatic metabolomics analysis were part of a larger metabolomics study of the plasma, kidney, heart, and lungdata from which have been reported 6,15

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ES2 had non-significant changes on the numbers of white blood cells, platelets, or red blood cells over the four-week experiment