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[16] The total amount of vitamin B-12 stored in body is about 2,000-5,000 mcg in adults

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NNMT inhibition or NNMT knockdown significantly increases energy expenditure, reduces body weight and white adipose mass, improves insulin sensitivity, and normalizes glucose tolerance and fasting blood glucose levels

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As such, some studies have suggested treatment of B12 may have a beneficial effect on the sleep-wake cycle and may help people suffering from delayed sleep phase syndrome