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Chesterfield, R

However, unlike mGluR5 in Group I, activation of mGluR7 in Group III reduced NMDA-mediated currents and NR1 surface expression in rodent basal forebrain cholinergic neurons through the regulatory mechanism of cofilin (CFL)

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In that sense, combining galunisertib, a small molecule inhibitor of TGFRI, with sorafenib and ramucirumab in HCC is currently under evaluation (189, 193)