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A., Rousseau, M

Held, M

American Journal of Physiology (Renal Physiology) 289: F1040F1047

Elevated homocysteine levels have been linked to the increased risk of cardiovascular disease, stroke, osteoporosis, Alzheimers disease, Parkinsons disease, dementia, diabetes and more (Rizzo et al., 2016

Using a flow cytometry-based assay for intracellular glutathione, we found that although melatonin increased cellular GSH levels, this effect was lost when cells were co-treated with melatonin and IKE ( Figure 6I )

The overexpression of antioxidant molecules such as GSH and SOD2, or chaperones such as Hsp70 has proved to be a successful experimental approach in brain diseases, including PD