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ACS Synth Biol 8:7081

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The neuroprotective effects of the ketogenic diet further extend to synaptic plasticity regulation: by increasing -hydroxybutyrate (BHB) levels, it directly activates the ERK/CREB signaling pathway in the hippocampus, promoting brain-derived neurotrophic factor (BDNF) synthesis (especially in females) to restore impaired long-term potentiation (LTP) in Alzheimers model mice

Yuneva MO, Fan TW, Allen TD, Higashi RM, Ferraris DV, Tsukamoto T, Mates JM, Alonso FJ, Wang C, Seo Y, Chen X, Bishop JM

In addition to its barrier-sealing effects, L-Glutamine directly influences immune cell behavior

Differential observations suggest that the role of caveolin 1 in hepatic lipid accumulation may differ depending on how the steatosis is induced, e.g., via high fat diet or fasting