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Source : Higashi Y., et al

10.1016/j.tox.2020.152599 168 YaoF.DengY.ZhaoY.MeiY.ZhangY.LiuX.et al (2021)

And many granting agencies, sadly, will not fund work until it's already basically done, believe it or not

Increased frequency of large local reactions among systemic reactors during subcutaneous allergen immunotherapy

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However, it is always the best of ideas to consult your dermatologist before taking up any skin ingredient when you are expecting or are already a nursing mother