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Other candidates include people who've experienced nerve damage from nitrous oxide exposure (sometimes called "laughing gas neuropathy") and those battling unexplained fatigue or neurological symptoms that haven't responded to other treatments

5-Amino-1MQ has no peptide bonds to cleave

The critical distinction with AOD-9604 is its complete lack of effect on IGF-1 levels

A randomized controlled trial in 167 older adults (50 years) found two-year supplementation with vitamin B 12 (10 g/day), along with folic acid (200 g/day), vitamin B6 (10 mg/day), riboflavin (5 mg/day), and vitamin D (10 g/day), had no effect on bone mineral density (total hip, femoral neck, or lumbar spine) compared to the control group only receiving vitamin D (10 g/day ) (116)

doi: 10.1124/jpet.102.047712

They should be approached with realistic expectations and appropriate screening