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doi: 10.1016/j.neuro.2010.05.012

During an extended open-label study ( N = 343), Reference Fernandez, Stamler and Davis60 76% of participants received at least 54 weeks of treatment and 35% of participants reached the highest daily dose of 48 mg by week 80

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This approach emphasizes that their utility is not standalone but as components of a personalized plan that simultaneously addresses psychological factors (e.g., through CBT), promotes graded exercise, and improves sleep hygiene

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