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Similarly, long-lasting modulation of glutamatergic transmission in VTA DA neurons have been observed after BDZ treatment, including the increase in ratio of AMPA/NMDA receptors 71

[ 134 ] Both HIPs and RM are effective for enhancing the drug delivery of macromolecules, but they remain susceptible to dilution, competition with endogenous molecules, and changes in the physiological environment

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The encouraging part is that this kind of environment-driven pigmentation is very treatable
