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(2017) which involved 144 patients requiring enteral nutrition, a fat-modified enteral formula containing MCT, carnitine, and taurine was compared to a standard enteral formula

[DOI] [PubMed] [Google Scholar] 131.Barnes CA, Markowska AL, Ingram DK, Kametani H, Spangler EL, Lemken VJ, Olton DS

In NPC cells, CPT1A was the only up-expressed carnitine palmitoyl transferase ( via isotope labeling that palmitate-derived carbons considerably augmented the Krebs cycle and could be integrated into nucleotide precursors such as aspartic acid, and pyrimidine nucleoside triphosphate ( de novo dNTP synthesis, and inhibits NPC cell cycles DNA replication at G1/S transition, implying a potential treatment strategy for NPC based on lipid metabolism regulation ( Furthermore, radiation resistance is still a significant barrier for NPC treatment ( via the PPAR coactivator-1 (PGC1)/CCAAT/enhancer binding protein (CEBPB)/CPT1A/FAO signaling axis ( CPT1A in leukemia In acute myeloid leukemia (AML), overexpression of CPT1A indicates poor clinical prognosis, and strong synergistic inhibitory effects on AML were seen when the CPT1A-selective inhibitor ST1326 and the Bcl-2 inhibitor ABT199 were applied in combination ( CPT1A as a target for cancer treatment CPT1A inhibitors can lessen the survivability of cancer cells, so CPT1A may be a useful target for cancer therapy

Inoue M, Rashid MH, Fujita R, Contos JJA, Chun J, Ueda H

Sci 26, 724733
