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Many people use these PPIs (Nexium, Prevacid or Protonix, ) for chronic heartburn and slowly etch away the lining of their GI tract

A competent RCT research question will encompass the participant population, the therapy/clinical intervention, outcomes, and it typically questions the effectiveness of one therapy versus another (or placebo) [17, 18]

doi: 10.1038/nrmicro2974

Some patients may require injections more frequently, and if a true deficiency is identified, several injections over 1-2 weeks are needed, known as a loading dose

Analyzing a series of studies using differing amounts of B12 via injection, the IOM determined that 1.5 g of absorbed B12 per day was enough to normalize red blood cell parameters (hematocrit, red blood cell volume, and anemia) in the average patient with pernicious anemia

Bidirectional communication between the ENS and the CNS, the gut-brain axis, integrates digestive and defensive functions of the gut with those of other organs to maintain homeostasis (710) (FIGURE 1)