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We then assessed whether LCS3 inhibits the downstream products of GSR and TXNRD1 activity within cells

Briefly, at typical physiological GSH concentrations and pH, the reaction between ONOO - and GSH will predominantly be a two electron oxidation process leading to GSSG formation (Quijano et al., 1997)

GHK-Cu activates and upregulates SIRT1, an enzyme that regulates the function of other proteins by deacetylating them, reducing the activity of STAT3

If they do, this would also add evidence that this NNMT inhibitor improves muscle performance through increasing NAD+ levels

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