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slightly lower resolution of this dataset, the Na + occupancy, or greater protein flexibility of the substrate-free conformation

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Knockout of the VDR gene in a Caco2 cell line showed a reduction in tight junction protein abundance and compromised function, while Vdr -/- mice have been shown to develop severe colitis compared to Vdr +/+ mice (140)

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doi: 10.1097/HCO.0b013e32835b0979 Dalal R, Grujic D (2024): Epinephrine
A study conducted by Xu et al
