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Markowitz et al, 1988

Patients taking any regular medications should consult their GP or pharmacist before starting supplementation

YC: Conceptualization, Formal Analysis, Investigation, Methodology, Writing - original draft

doi: 10.1016/j.berh.2024.101933 [DOI] [PubMed] [Google Scholar]

Subsequently many other mutations were found to be associated with familial forms of PD (Flagmeier et al., 2016) including the A30P mutant aggravating PD by reduced autophagic clearance of protein aggregates (Lei et al., 2019) and E46K mutant which promotes fibrillation of N acetylated -synuclein by abolishing the long-range electrostatic interactions (Zhao et al., 2020)

Introduce gradually over several weeks