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Code availability The computer code for the custom analyses is publicly available at as of the date of publication

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Consider dose reduction or interruption

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The blocks were cut using a diatome diamond knife and a Leica Ultracut T ultramicrotome and stained with 2% uranyl acetate and finally with Reynolds lead citrate for 30 and 15 min, respectively

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Very low-density lipoproteins (VLDLs) transport endogenous lipid from the liver to cells

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I've seen a good cumulative effect of a more defined lip rim with fewer lines to break up the shape

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