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Conversely, T2DM is often accompanied by pronounced insulin resistance and metabolic syndrome, leading to systemic inflammation and elevated oxidative stress [12, 13]

Ultrastructural mucosal alterations and increased intestinal permeability in non-celiac, type I diabetic patients

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Changes in the composition of the microbiota and microbial metabolites influence gut health and immune system reactions

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Additionally, Farashi showed that stem cells can reduce oxidative stress and improve their survival rates by secreting HSPs in low-temperature conditions (Farashi and Sharifi, 2021)