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As Dermatologist Katherine Armour, a Melbourne-based skin expert, says, "There is often a change in the appearance of many of their moles, such that it can be difficult to detect melanomas or sometimes, clinically, for us to exclude melanoma." Melanotan is classified as an unapproved product by Australias Therapeutic Goods Administration (TGA)

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Over time, Afamelanotide became one of the most studied melanocortin peptides, with clinical research evaluating its safety profile, receptor specificity, and long-term effects

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