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Therapeutic strategies targeting the TMAO pathway Given the established role of TMAO in promoting atherosclerosis, thrombosis, and adverse cardiovascular outcomes, significant interest has emerged in developing therapeutic strategies to attenuate TMAO production or block its pathological effects

Obesity A recent meta-analysis, summarized studies focused on LC supplementation for a prolonged time (median 3 months) [40]

L-arginine is one of the three amino acids (arginine, glutamine, and leucine) that can directly regulate mTORC1 activation and, thus, cell proliferation and apoptosis

10.1016/j.pharep.2014.04.009 5

This process is vital for maintaining energy levels during physical activity and supports a healthy metabolism

Increased circulating trimethylamine N-oxide contributes to endothelial dysfunction in a rat model of chronic kidney disease
