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In line with these findings, a potential toxic synergism between APAP and salicylates (e.g., aspirin) can result in liver failure, particularly in children, potentiated by the exhaustion of GSH levels (Nourjah et al., 2006) with a mortality rate of approximately 0.4% (450 deaths a year) in the United States (Yoon et al., 2016)

Neuron 15 , 417426 (1995)

Previously, we showed that TG2 mediates crystallin, caspase 3, and collagen crosslinking in response to oxidative stress, hypoxic stress, and DNA damage, which leads to cataract formation, apoptotic resistance, and fibrotic development, respectively 4,5,6

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