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In this way, our study unifies two key aspects of APR-246 activity: redox modulation and mut-p53-dependent killing of cancer cells 21

Voorgestelde routes in de literatuur omvatten interactie met het stikstofoxide-systeem en modulatie van groeifactor-signalering

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These results acquire additional significance, if one considers that resting gCl plays a pivotal role in total membrane conductance of sarcolemma and maintains the sarcolemmal electrical stability by shunting the depolarization-driven potassium accumulation (184)