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Warnings and precautions Ozempic also comes with more serious risks and precautions, though these are rare

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134 The role of GLP-1s in the setting of antidepressant medications, which could have both synergistic and opposing benefits and side effects, 135 requires more study

Figure 2 Importantly, in the SELECT trial, differences in rates of cardiovascular events between semaglutide and placebo began to emerge within the first few months suggesting that weight loss alone may not account for the full benefits ( On the co-morbidities front, GLP-1R is not expressed in the liver and the data generated with semaglutide in NASH patients seems to support a lack of a direct antifibrotic effect (152)