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These considerations emphasize the necessity for long-term, phenotype-specific research and limit the direct translation of findings into standardized treatment advice

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210 Acetyl-CoA then starts the TCA cycle, where NAD + serves as a coenzyme for three rate-limiting enzymes, -ketoglutarate dehydrogenase (KGDH), isocitrate dehydrogenase 3 (IDH3) and malate dehydrogenase (MDH2), to generate NADH

Moreover, recent findings indicate that elevated doses might lead to cytotoxic effects, especially within microglial populations, underscoring the necessity for meticulously adjusted dosing protocols

Additionally, Traditional Chinese Medicines or extracts with immunomodulatory effects could be employed to regulate the host immune microenvironment, enhancing the immune response against persistent bacteria