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Activation of SIRT1 has been shown to boost the expression of antioxidant genes by deacetylating and activating Nrf2, subsequently mitigates cell damage caused by oxidative stress and dysregulated iron metabolism

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154 Besides the bioenergetics stimulation, the antioxidant nature of H 2 S is expected to protect cancer cells from oxidative damage

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IRS1Y608 is the primary site of interaction between IRS1 and the SH2 structural domain of PI3K and phosphorylation of the S612 residue prevents phosphorylation of the Y608 residue (117)

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As an antioxidant, GSH scavenges harmful oxygen-containing molecules known as reactive oxygen species (ROS) and neutralizes them

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Appendix A Appendix B Table A1

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influenzae infection contributes to Th17- and neutrophil-driven inflammation and steroid insensitivity in allergic respiratory disease

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