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Whilst observational studies suggest that regular oral coffee consumption may benefit liver health, coffee enemas carry significant risks including rectal perforation, electrolyte disturbances, and infection

Morscher RJ, Aminzadeh-Gohari S, Feichtinger RG, Mayr JA, Lang R, Neureiter D et al

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doi: 10.2147/CIA.S67449

Under the condition of oxidative stress, intricate interactions occur among apoptosis, autophagy, and ferroptosis