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Keywords: methylglyoxal, glyoxalase, dicarbonyl stress, diabetes, cancer chemotherapy, malaria, resveratrol, SARS-CoV-2 1

Generation of a selective senolytic platform using a micelle-encapsulated Sudan Black B conjugated analog

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As direct validation of target proteins with recombinant enzymes in vitro was challenging, we favoured the native activation of 5-nitroimidazoles as a key step to evaluate their target preferences and deliberately avoided artificial activation mechanisms by, for example, chemical reduction in vitro 27,45

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Lei Y., et al