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The consequences are not trivial: unlike aminoglycoside nephrotoxicity, which typically resolves after drug discontinuation, ototoxicity produces permanent sensorineural hearing loss (Schacht et al., 2012

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Biosynthetic pathways: Acetyl-CoA also serves as a precursor for fatty acid synthesis, cholesterol synthesis, and the synthesis of other important biomolecules

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Remarkably, it has been verified to improve SLE patients by recovering mitochondrial dysfunction (206208)