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Participants included adults who had been using GLP-1 for at least three months

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Tirzepatide has shown cardiovascular benefits in major clinical trials, but heart patients need individualized assessment before starting GLP-1 therapy

To conclude, the food intake reducing effects of exenatide may temporally evolve from strong anorectic to weak anhedonic modulations, where hedonic experience and anticipation during the early anorectic phase is conserved but uncoupled from food intake behaviour.