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Further studies using knockout animals indicate that at least in rodents peroxiredoxin 2 and glutaredoxin 1 are the major enzymes detoxifying endogenous H 2 O 2 in RBC (Lee et al., 2003

[DOI] [PMC free article] [PubMed] [Google Scholar] 39.Chen Z., Wang W., Razak A., Han T., Ahmad N.H., Li X

Two primary mechanisms are thought to be responsible for the molecular basis of polyphenols' antioxidant activity: either they directly interact with the reactive oxygen species as primary antioxidants or they involve the chelation of free metals as secondary antioxidants

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Moller et al., 2007)
