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The total weekly dose remains 8mg, but the peak plasma concentration is lower, which reduces GI symptoms for many researchers

Modulation of the Gut Microbiota for Prevention and Treatment: From Biology to Clinic Given the gut microbial contribution to inflammatory disease and the immune system, there exists an opportunity to intentionally modulate the microbiome for therapeutic purposes

& Dreyer, J.-L

Kennedy previewed the move in an interview with podcast host Joe Rogan

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[DOI] [PubMed] [Google Scholar] Zhen X, Zhang J, Johnson GP, Friedman E (2001) D(4) dopamine receptor differentially regulates Akt/nuclear factor-kappa b and extracellular signal-regulated kinase pathways in D(4)MN9D cells