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This distinction is essential in any clinical or research discussion

Furthermore, GLP-1 has beneficial cardiovascular effects in humans by lowering blood pressure and improving myocardial function [20, 21], although in rats this peptide significantly increases arterial blood pressure and heart rate [22, 23]

However, their possible contributions toward cardiac function impairment in HF patients are not completely known

Nevertheless, the low or very low certainty of evidence underscores the need for larger population studies with standardized exposure definitions, detailed outcome classification, and comprehensive adjustment for confounding