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Even so, in healthy adults, even with strict vegetarian patterns, a clinical deficiency is uncommon because endogenous synthesis usually meets needs, although context (age, nutritional status, illness) can modify this situation

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doi:10.1210/endo.136.5.7720654 pmid:7720654 Gottlieb HB, Ji LL, Jones H, Penny ML, Fleming T, Cunningham JT (2006) Differential effects of water and saline intake on water deprivation-induced c-Fos staining in the rat
