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(10 June 2020)
C., & Malysz, T
PMID: 41209547 References are provided for research reference only
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The gamma(1)34.5 protein of herpes simplex virus 1 complexes with protein phosphatase 1alpha to dephosphorylate the alpha subunit of the eukaryotic translation initiation factor 2 and preclude the shutoff of protein synthesis by double-stranded RNA-activated protein kinase
In short, 5-Amino-1MQ acts as a metabolic/epigenetic node by inhibiting NNMT, thereby impacting NAD flux and methylation potential rather than directly activating a receptor
