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The cause of these deposits is uncertain, but they are thought to be the result of oxidative stress
169 (Suppl 3), 4156 (2013)

They will also increase telomer shortening leading to potential aging

Consequently, the maleimide functionality is mainly introduced via post-synthetic amide-couplings in solution-phase, where amino-modified oligonucleotide (AON) reacts with activated esters (see Fig

Cys-Gly can be cleaved by membrane-bound dipeptidases (MDBs) or intracellular Cys-Gly peptidases

Interestingly, the number of mitochondria in synapses is very high
