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3 Advances in emerging drug therapies: genetically targeted therapies TDP-43 is an RNA-binding protein, and cytoplasmic TDP-43 aggregates are present in sporadic and familial ALS, in addition to familial ALS caused by mutations in SOD1 , and its aberrant aggregation and aberrant function have been implicated in the pathogenesis of ALS (31, 32)

Mild side effects may occur but are generally temporary

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In the 1960s, GPX activity was noticed in other tissues, including the lungs and kidneys, and shown to reduce hydroperoxide-type compounds including H 2 O 2 [2,3]

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