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Consequently, the significantly elevated lactate levels in tumor tissues5- to 20-fold higher than in normal tissues, constitute a core metabolic feature that directly drives lactylation, whereas acetylation and succinylation are subject to cross-regulation by diverse metabolic inputs, rendering them relatively less specific as indicators of particular metabolic states (7, 43)

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Blood-gas analysis showed metabolic acidosis and a blood-ammonia level of 85.4 mol/L (1872 mol/L)

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