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A case series reported five women who developed acneiform eruptions from B12 therapy: three from injections alone, one from combined B12 and B6 injections, and one from an oral B-vitamin combination

Determination of biothiols by bromobimane labeling and high-performance liquid chromatography
Glutathione peroxidase, an enzyme which protects hemoglobin from oxidative breakdown
Carmona M

Additionally, the absence of reliable and objective measures to assess the efficacy of drugs may also contribute to unfavorable results
